Stéphane AVRIL

  • Responsibilities and Duties
  • Research Topics
    • Biomechanics of biological soft tissues: in vivo characterization of material properties, patient-specific predictive modeling, medical compression, elastography.
    • Aortic digital twin: read the post.
    • Prevention of aneurism rupture: biomechanics of the aortic wall, damage mechanisms in fibrous tissues, stent-graft modeling, patient-specific predictive simulation of endovascular interventions, biolochanics.
    • Inverse problems: identification of constitutive parameters using full-field measurements, theoretical development of the virtual fields method and application to experimental data in elasticity, elastoplasticity and elastoviscoplasticity (software CamFit).
    • Biomechanics serving Healthcare – Read the press release
  • Teaching Areas

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  • Biography

    Stéphane Avril is a distinguished Full Professor at Institut Mines Telecom affiliated at Mines Saint-Etienne in France. He runs a group of 20+ in soft tissue biomechanics, with a special focus on constitutive modeling and identification using imaging techniques. He was the director of the CIS center for biomedical and healthcare engineering (70+ people) between 2010 and 2020 and has been the deputy director of SAINBIOSE (INSERM endorsed laboratory with 100+ researchers) since 2016. Stéphane received his PhD in mechanical and civil engineering in 2002 at Mines Saint-Etienne (France). After positions at Arts et Métiers ParisTech (France) and Loughborough University (UK) where he developed the Virtual Fields Methods, Stéphane returned to his alma mater in 2008 and extended his broad experience of inverse problems to soft tissue biomechanics, especially regarding aortic aneurisms in close collaboration with vascular surgeons. Stéphane was a visiting Professor at the University of Michigan Ann Arbor (USA) in 2008 and has been a visiting professor at Yale University between 2014 and 2019. Since September 2020, Stéphane is a guest professor at TU Vienna in Austria.
    Stéphane has received many awards and distinctions including ICCB best communication award (2017), Editor’s Choice Paper Finalist – ASME Journal of Biomechanical Engineering (2016), ESB best poster award (2015), BSSM 50th Anniversary Plenary Speaker (2014). He has led two national ANR grants in soft tissue biomechanics and supervised 25+ PhD students. In 2015, Stéphane was awarded an ERC (European Research Council) consolidator grant of 2m€ for the Biolochanics project on: Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine.
    Most of Stéphane’s research is aimed at improving the treatment of cardiovascular diseases by assisting physicians and surgeons with biomechanical numerical simulations.
    In 2017, Stéphane co-founded Predisurge, a spin-off company of IMT at Mines Saint-Etienne. PrediSurge offers innovative software solutions for patient-specific numerical simulation of surgical procedures. First applications in endovascular aneurysm repair (EVAR) enable the automatic design of fully-customized fenestrated stent-grafts. Preliminary evaluations reveal huge benefits for the 20000+ patients requiring fenestrated EVAR every year: faster procedures, increased precision, near-zero risk of complications. Our vision for 2025 is that all EVAR procedures will have to be numerically simulated for ensuring the highest degree of safety.

  • Education
    • PhD in Mechanical and Civil Engineering, Mines Saint-Etienne, France (2002).
    • MSc in Mechanical Engineering with a specialization in Mathematics, Mines Saint-Étienne, France (1999).
  • Career History

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  • Main Publications

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  • Distinctions

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168 documents

  • Baptiste Pierrat, Vít Novácěk, Stéphane Avril, Frédéric Turquier. Mechanical characterization and modeling of knitted textile implants with permanent set. Journal of the mechanical behavior of biomedical materials, Elsevier, 2021, 114, pp.104210. ⟨10.1016/j.jmbbm.2020.104210⟩. ⟨hal-03139999⟩
  • Salvatore Campisi, Raja Jayendiran, Francesca Condemi, Magalie Viallon, Pierre Croisille, et al.. Significance of Hemodynamics Biomarkers, Tissue Biomechanics and Numerical Simulations in the Pathogenesis of Ascending Thoracic Aortic Aneurysms. Current Pharmaceutical Design, Bentham Science Publishers, In press, ⟨10.2174/1381612826999201214231648⟩. ⟨hal-03139798⟩
  • Lauranne Maes, Julie Vastmans, Stéphane Avril, Nele Famaey. A chemomechanobiological model of the long-term healing response of arterial tissue to a clamping injury. Frontiers in Bioengineering and Biotechnology, Frontiers, 2021, 8, pp.589889. ⟨10.3389/fbioe.2020.589889⟩. ⟨hal-03139778⟩
  • Di Zuo, Stéphane Avril, Chunjiang Ran, Haitian Yang, S. Jamaleddin Mousavi, et al.. Sensitivity analysis of non‐local damage in soft biological tissues. International Journal for Numerical Methods in Biomedical Engineering, John Wiley and Sons, In press, ⟨10.1002/cnm.3427⟩. ⟨hal-03139932⟩
  • Marzio Di Giuseppe, Solmaz Farzaneh, Massimiliano Zingales, Salvatore Pasta, Stéphane Avril. Patient-Specific Computational Evaluation of Stiffness Distribution in Ascending Thoracic Aortic Aneurysm. Journal of Biomechanics, Elsevier, In press, pp.110321. ⟨10.1016/j.jbiomech.2021.110321⟩. ⟨hal-03139856⟩
  • Claudie Petit, Ali-Akbar Karkhaneh Yousefi, Olfa Ben Moussa, Jean-Baptiste Michel, Alain Guignandon, et al.. Regulation of SMC traction forces in human aortic thoracic aneurysms. Biomechanics and Modeling in Mechanobiology, Springer Verlag, In press, ⟨10.1007/s10237-020-01412-6⟩. ⟨hal-03139718⟩
  • Dar Weiss, Cristina Cavinato, Authia Gray, Abhay Ramachandra, Stéphane Avril, et al.. Mechanics-driven mechanobiological mechanisms of arterial tortuosity. Science Advances , American Association for the Advancement of Science (AAAS), 2020, 6 (49), pp.eabd3574. ⟨10.1126/sciadv.abd3574⟩. ⟨hal-03139747⟩
  • Ataollah Ghavamian, S Mousavi, Stéphane Avril. Computational Study of Growth and Remodeling in Ascending Thoracic Aortic Aneurysms Considering Variations of Smooth Muscle Cell Basal Tone. Frontiers in Bioengineering and Biotechnology, Frontiers, 2020, 8, ⟨10.3389/fbioe.2020.587376⟩. ⟨hal-03139670⟩
  • Miquel Aguirre, Stéphane Avril. An implicit 3D corotational formulation for frictional contact dynamics of beams against rigid surfaces using discrete signed distance fields. Computer Methods in Applied Mechanics and Engineering, Elsevier, 2020, 371, pp.113275. ⟨10.1016/j.cma.2020.113275⟩. ⟨hal-03139761⟩
  • Raja Jayendiran, Salvatore Campisi, Magalie Viallon, Pierre Croisille, Stéphane Avril. Hemodynamics alteration in patient-specific dilated ascending thoracic aortas with tricuspid and bicuspid aortic valves. Journal of Biomechanics, Elsevier, 2020, 110, pp.109954. ⟨10.1016/j.jbiomech.2020.109954⟩. ⟨hal-03129206⟩