{"id":7,"date":"2024-12-13T13:57:28","date_gmt":"2024-12-13T12:57:28","guid":{"rendered":"https:\/\/www.mines-stetienne.fr\/juven-twin-fr\/?page_id=7"},"modified":"2025-01-13T15:55:59","modified_gmt":"2025-01-13T14:55:59","slug":"le-projet","status":"publish","type":"page","link":"https:\/\/www.mines-stetienne.fr\/juven-twin-fr\/le-projet\/","title":{"rendered":"Le projet JuvenTwin"},"content":{"rendered":"\n

Le vieillissement vasculaire<\/strong> joue un r\u00f4le cl\u00e9 dans de nombreuses maladies chroniques. Un des principaux facteurs de risque associ\u00e9s \u00e0 ce processus est l\u2019augmentation de la rigidit\u00e9 art\u00e9rielle<\/strong>. Lorsque les art\u00e8res perdent leur \u00e9lasticit\u00e9, elles ne peuvent plus absorber efficacement les fluctuations de la pression art\u00e9rielle, ce qui peut pr\u00e9c\u00e9der des probl\u00e8mes tels que l\u2019hypertension et conduire \u00e0 diverses pathologies graves.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Les cons\u00e9quences de la rigidit\u00e9 art\u00e9rielle<\/h2>\n\n\n\n
    \n
  • Les maladies cardiaques<\/strong> (35 % des plus de 65 ans) : La rigidit\u00e9 art\u00e9rielle surcharge le ventricule gauche, provoquant une insuffisance cardiaque qui peut \u00e9voluer jusqu\u2019\u00e0 une crise cardiaque.<\/li>\n\n\n\n
  • Les maladies c\u00e9r\u00e9brovasculaires et la d\u00e9mence<\/strong> (15 % des plus de 65 ans) : Elle entra\u00eene des micro-dommages dans les vaisseaux du cerveau, jouant un r\u00f4le dans des pathologies telles qu\u2019Alzheimer<\/strong> et Parkinson<\/strong>.<\/li>\n<\/ul>\n\n\n\n

    Une approche novatrice : les jumeaux num\u00e9riques multi-\u00e9chelles<\/h2>\n\n\n\n

    Pour contrer ces probl\u00e8mes, le projet JuvenTwin propose une nouvelle approche scientifique<\/strong> bas\u00e9e sur l\u2019utilisation de jumeaux num\u00e9riques multi-\u00e9chelles<\/strong>. Ces mod\u00e8les avanc\u00e9s permettent d\u2019\u00e9tudier et de tenter d\u2019inverser la rigidification art\u00e9rielle li\u00e9e \u00e0 l\u2019\u00e2ge.<\/p>\n\n\n\n

    Contrairement aux approches actuelles qui ciblent principalement les sympt\u00f4mes, cette m\u00e9thode vise \u00e0 restaurer les propri\u00e9t\u00e9s m\u00e9caniques des cellules vasculaires<\/strong>, permettant ainsi un rajeunissement des art\u00e8res<\/strong>.<\/p>\n\n\n\n

    Des enjeux complexes<\/h2>\n\n\n
    \n
    \"\"<\/figure>\n<\/div>\n\n\n

    Bien que prometteuse, cette strat\u00e9gie comporte des risques \u00e9lev\u00e9s<\/strong>, car les forces m\u00e9caniques dans les art\u00e8res interagissent avec des processus biologiques complexes, tels que :<\/p>\n\n\n\n

      \n
    • L\u2019inflammation<\/strong>,<\/li>\n\n\n\n
    • L\u2019expression des g\u00e8nes<\/strong>.<\/li>\n<\/ul>\n\n\n\n

      Pour garantir un \u00e9quilibre, le projet s\u2019appuie sur des mod\u00e8les num\u00e9riques avanc\u00e9s<\/strong> afin d\u2019\u00e9tudier ces interactions et de d\u00e9velopper des th\u00e9rapies \u00e0 la fois efficaces et s\u00fbres<\/strong>.<\/p>\n\n\n\n

      Objectifs du projet JuvenTwin<\/h2>\n\n\n\n

      L\u2019objectif principal du projet est de r\u00e9tablir une r\u00e9gulation m\u00e9canique stable<\/strong> dans les art\u00e8res des patients, lorsque celle-ci est alt\u00e9r\u00e9e par le vieillissement. Pour y parvenir, JuvenTwin se concentre sur :<\/p>\n\n\n\n

        \n
      • L\u2019analyse des m\u00e9canismes<\/strong> par lesquels les cellules art\u00e9rielles g\u00e8rent les forces m\u00e9caniques.<\/li>\n\n\n\n
      • La compr\u00e9hension des processus<\/strong> responsables de la d\u00e9gradation progressive de cette r\u00e9gulation avec l\u2019\u00e2ge.<\/li>\n\n\n\n
      • L\u2019identification de solutions personnalis\u00e9es<\/strong> permettant de restaurer cette r\u00e9gulation de mani\u00e8re efficace.<\/li>\n<\/ul>\n\n\n\n

        Un impact pour tous les citoyens europ\u00e9ens<\/h2>\n\n\n\n

        \u00c0 terme, JuvenTwin pourrait ouvrir la voie \u00e0 des th\u00e9rapies pr\u00e9ventives<\/strong> pour lutter contre le durcissement des art\u00e8res et prolonger la vie en bonne sant\u00e9<\/strong> des citoyens de l\u2019Union europ\u00e9enne.<\/p>\n\n\n\n

        Les jumeaux num\u00e9riques multi-\u00e9chelles : une technologie r\u00e9volutionnaire<\/h2>\n\n\n\n

        Les jumeaux num\u00e9riques multi-\u00e9chelles<\/strong> sont des mod\u00e8les num\u00e9riques avanc\u00e9s reproduisant, \u00e0 diff\u00e9rentes \u00e9chelles (du niveau cellulaire au niveau organique), les comportements, interactions et m\u00e9canismes d\u2019un syst\u00e8me biologique, physique ou m\u00e9canique. Cette technologie est au c\u0153ur de l\u2019innovation port\u00e9e par JuvenTwin.<\/p>\n","protected":false},"excerpt":{"rendered":"

        Le vieillissement vasculaire joue un r\u00f4le cl\u00e9 dans de nombreuses maladies chroniques. Un des principaux facteurs de risque associ\u00e9s \u00e0 ce processus est l\u2019augmentation de la rigidit\u00e9 art\u00e9rielle. Lorsque les art\u00e8res perdent leur \u00e9lasticit\u00e9, elles ne peuvent plus absorber efficacement les fluctuations de …<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-7","page","type-page","status-publish","hentry"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"yoast_head":"\nLe projet JuvenTwin - JuvenTwin<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mines-stetienne.fr\/juven-twin-fr\/le-projet\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le projet JuvenTwin - JuvenTwin\" \/>\n<meta property=\"og:description\" content=\"Le vieillissement vasculaire joue un r\u00f4le cl\u00e9 dans de nombreuses maladies chroniques. 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